Image content features models and is intended for illustrative purposes only. Please contact your local laboratory for more information. This test is offered as QNatal Advanced in all states other than California. “No call rate” refers to the percentage of samples for which results could not be reported. doi:10.1002/mgg3.545 (finding a no-call rate of 3.5% several authors affiliated with Quest Diagnostics). Prenatal cell-free DNA screening for fetal aneuploidy in pregnant women at average or high risk: Results from a large US clinical laboratory. QNatal Advanced is a laboratory developed test that has been developed and validated, pursuant to the Clinical Laboratory Improvements Amendments of 1988 (CLIA), and as such it has not been reviewed by FDA.ĭ Guy C, Haji-Sheikhi F, Rowland CM, et al. Performance data for the QNatal Advanced may be obtained by contacting Quest Diagnostics at 1. (1.866.436.3463). The positive predictive value of the screening test varies by genetic marker, and may be lower for rare conditions. As with any test, there may be false positives or false negatives. Appointments take priority over walk-ins. Pregnancy management decisions should not be based on the results of a cfDNA test alone. Make an appointment now and youll have little to no wait time when you arrive. QNatal is a “screening” test, not a diagnostic test, and therefore all positive/increased risk results should be followed by genetic counseling and further diagnostic testing and procedures, when clinically indicated.

QNatal Advanced is not recommended before 10 weeks gestation due to a significantly increased risk of a failed result. QNatal Advanced must not be used earlier than 10 weeks into pregnancy.

This test does not assess the risk of fetal anomalies such as neural tube defects or ventral wall defects. In addition, if selected as an option, QNatal Advanced can screen for certain microdeletions (ie, 22q, 5p, 1p36, 15q, 11q, 8q, and 4p) that may cause birth defects, and/or for fetal sex. Quest Diagnostics, 2020.ī Alternative UPP pricing is available in Florida, New Hampshire, Massachusetts, Maine, Rhode Island, Vermont, and TexasĬ QNatal ® Advanced is a cell-free DNA test that screens for increased risk of certain fetal chromosomal abnormalities that may cause birth defects, including Trisomy 21 (Down Syndrome), Trisomy 18, Trisomy 13, and certain sex chromosome abnormalities (ie, 45,X, 47,XXY, 47,XXX, and 47,XYY).

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